(S,S)-Secoisolariciresinol diglucoside

Research use only, not for human use.

(S,S)-Secoisolariciresinol diglucoside ((S,S)-SDG) is a lignan present in flaxseed with anti-inflammatory, antioxidant, anti-microbial and neuroprotective properties and can be used in the study of obesity, arthritis and osteoporosis.

Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects.

Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals.Secoisolariciresinol diglucoside (1-50 μM; 24 h) attenuates human monocyte adhesion to and migration across human brain endothelial monolayers.

Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation.Animal Model:Hand feeding mice (10 weeks old, male) are injected with TNFα Dosage:4 mg/mouse Administration:P.o. 2 h before i.c. administration of TNFα Result:Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%.

——

Others

Antioxidant

Antioxidant

——

——

257930-74-8

686.7

C32H46O16

>98% (HPLC)

In Vitro:?H2O : ≥ 100 mg/mL (145.62 mM)

[C@@H]([C@H](CC1=CC(OC)=C(O)C=C1)CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)(CC3=CC(OC)=C(O)C=C3)CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O

——

(-20℃)

With Ice Pack

≥ 2 years